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  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
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    • Laser-induced Choroidal Neovascularization
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Preclinical Ophthalmic Contract Research

News

Investigator-Sponsored Phase 2 Study Results Show pSivida’s Medidur® Fully Controlled Uveitis for Two Years with No Recurrence of Disease While Visual Acuity Continued to Improve

July 27, 2016 //  by stanselb

WATERTOWN, Mass., July 14, 2016 (GLOBE NEWSWIRE) -- pSivida Corp. (NASDAQ:PSDV) (ASX:PVA), a leader in the development of sustained release drug delivery products primarily for eye diseases, announced that the results from an investigator-sponsored Phase 2 study of pSivida’s Medidur showed no recurrence of uveitis in 11 eyes treated with Medidur during the two years following implantation, while …

Category: NewsTag: drug delivery, eye health, Ophthalmology, research, uveitis, visual acuity

Gene-based agents for the treatment of congenital eye diseases

July 7, 2016 //  by stanselb

Pharmacologists at LMU have developed gene-based agents for the treatment of congenital eye diseases. The first of these is now undergoing a phase-I clinical trial in color-blind patients at the University Medical Center in Tübingen. Is this approach translatable in principle to other visual disorders? Michalakis: About 200 genes have been identified which, when mutated, lead to monogenetic …

Category: NewsTag: blindness, eye health, gene therapy, ophthalmic research, retinitis pigmentosa, visual acuity

Roche CEO ‘sleeps better’ as risk to drugmaker’s growth recedes

June 28, 2016 //  by stanselb

LONDON (Reuters) - Roche (ROG.S) is increasingly confident it will continue to lift sales and profit even as cut-rate copies of the Swiss drugmaker's older cancer medicines start to grab business next year, its chief executive said on Wednesday. In February the company won U.S. Food and Drug Administration (FDA) breakthrough status for new multiple sclerosis drug Ocrevus. That was followed in …

Category: NewsTag: biotechnology, research

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.

June 15, 2016 //  by stanselb

Retinal degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment are being sought actively. Here we explored the activation of a unique protein, sigma 1 receptor (Sig1R), in the treatment of PRC loss because of its multifaceted role in cellular survival.  We used Pde6βrd10 (rd10) mice, which harbor a mutation in the rod-specific phosphodiesterase gene …

Category: NewsTag: blindness, electroretinogram, OCT, ophthalmology research, optical coherence tomography, retina, retinal degeneration

Prismatic eyewear for patients with tunnel vision to launch

June 7, 2016 //  by stanselb

A trio of eyeglasses using revolutionary prism techniques could open up a whole new field of view for patients with hemianopia.  The three designs – yoked prisms in a carrier lens, a bi-part double Fresnel prism, and the mirror-based periscopic prisms – were showcased in the journal Optometry and Vision Science.  Lead researcher and Harvard Medical School ophthalmology professor, Dr Eli Peli, told …

Category: NewsTag: Ophthalmology, research, vision

Intraocular therapy prevents or reverses diabetic retinopathy in mice

June 2, 2016 //  by stanselb

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin …

Category: NewsTag: blindness, diabetes, Diabetic retinopathy, ophthalmic research, Ophthalmology, retina, vision loss

Retinal Remodeling And Metabolic Alterations in Human AMD

May 24, 2016 //  by stanselb

Age-related macular degeneration (AMD) is a progressive retinal degeneration resulting in central visual field loss, ultimately causing debilitating blindness.  While many genetic and environmental risk factors are known for AMD, we currently know less about the mechanisms mediating disease progression.  The goal of this article is to illustrate cell types impacted in AMD and demonstrate the …

Category: NewsTag: Age-related macular degeneration, AMD, blindness, ophthalmic research, Ophthalmology, retina, retinal pigment epithelium, retinal remodeling, retinitis pigmentosa, RP, RPE, vision loss

Avalanche Biotechnologies Closes Transaction With Annapurna Therapeutics

May 12, 2016 //  by stanselb

Avalanche Biotechnologies, Inc. (AAVL) today announced the closing of the previously announced transaction with Annapurna Therapeutics.  “The new management team is focused on applying our extensive clinical development expertise to advance the company’s gene therapy programs into the clinic.  We intend on dosing our first patients for A1AT deficiency by the end of this year and for HAE in 2017 …

Category: NewsTag: Age-related macular degeneration, Avalanche Biotechnologies, clinical development, eye disease, gene therapy, wet amd

eyecro data to be presented at ARVO 2016 in Seattle

April 29, 2016 //  by stanselb

…

Category: NewsTag: ARVO, MiDROPS, Ophthalmology, research

Nerve Injury Appears to be Root of Diabetes-related Vision Loss

April 18, 2016 //  by stanselb

Diabetes-related vision loss most often is blamed on blood vessel damage in and around the retina, but new research indicates that much of that vision loss may result from nerve cell injury that occurs long before any blood vessels are damaged.  After three months on a high-fat diet, the animals had developed obesity-related glucose intolerance, and by six months, they had nerve problems in the …

Category: NewsTag: blindness, blood vessel damage, diabetes-related vision loss, retina, vision loss

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