DL-AAA Retinal Leakage

DL-alpha-aminoadipic acid (DL-AAA) is a selective Müller cell toxin that leads to retinal leakage and neovascularization after intravitreal administration in rabbits. The mechanism of action is driven by VEGF and agents such as aflibercept have shown efficacy in this model: Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration