VEGF-induced permeability

Vascular endothelial growth factor (VEGF)-driven retinal vascular leakage is a central pathological feature of diseases such as diabetic macular edema, retinal vein occlusion, and wet age-related macular degeneration. Direct VEGF-induced permeability models provide a rapid and controlled system for evaluating anti-permeability therapeutics.

Model Overview

Retinal vascular leakage is induced by intravitreal delivery of recombinant VEGF protein or other permeability-inducing factors. Breakdown of the blood-retinal barrier is then quantified using fluorophotometry, providing a direct and sensitive measurement of therapeutic efficacy.

Typical Endpoints

  • Fluorophotometry (retinal vascular leakage quantification)

Representative Data

VEGF permeability

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