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https://eyecro.com

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Mitochondrial Neuropathy
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
    • A2E Quantification
    • Bioanalytical Detection
    • Biochemistry
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

Corneal Sensitivity

The cornea is the most densely innervated structure in the body. Corneal nerves are responsible for the sensations of touch, pain, and temperature. Corneal innervation plays essential role in the blink reflex, wound healing, and tear production. Corneal nerve loss/ dysfunction is frequently observed in diseases that lead to opacities and often corneal blindness. For example, corneal nerves often suffer damage during injury/trauma, surgical intervention, microbial infection, diabetic mellitus, and dry eye disease. Corneal innervation can be evaluated for both function and morphology using standard instruments, such as a corneal esthesiometer and β-III tubulin nerve staining.

corneal nerve labeling and quantification
Imaging of corneal sub-basal nerves and automated quantification of nerve length/density
corneal sensation with sedation
Quantification of corneal sensation with/without topical sedation using a Cochet-Bonnet aesthesiometer

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