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https://eyecro.com

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Mitochondrial Neuropathy
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
    • A2E Quantification
    • Bioanalytical Detection
    • Biochemistry
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

Diabetic Keratopathy

Patients with diabetes often have corneal epithelial defects that persist or are unresponsive to conventional treatments. This complication of diabetes is known as diabetic keratopathy (DK). DK often presents as decreased corneal sensitivity, increased epithelial fragility, decreased wound healing, secondary scarring, punctate keratopathy, and edema. Additional complications include surface irregularities, corneal infections, and stromal opacifications. Loss of corneal sensitivity is caused by a hyperglycemia induced reduction in corneal innervation. This leads to a reduction of reflex-induced lacrimal stimulation and blink rate, resulting in greater tear evaporation. This reduction of tears leads to dry eye disease in many diabetic patients.

corneal touch threshold graphs

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