MNU-induced Retinal Degeneration
N-methyl-N-nitrosourea (MNU) is a potent mutagen that drives a reproducible rod-cone degeneration of the retina through apoptosis of the photoreceptors. Multiple reports also implicate mitochondrial dysfunction that contributes to the visual function loss and neuronal cell death
![](https://eyecro.com/wp-content/uploads/2023/04/MNU-degeneration-HE-2000x991.png)
![MNU-induced retinal degeneration](https://eyecro.com/wp-content/uploads/2023/04/MNU-degeneration-2000x760.png)