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EyeCRO

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Blue Light Damage
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Mitochondrial Neuropathy
    • MNU-induced Retinal Degeneration
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
    • A2E Quantification
    • Bioanalytical Detection
    • Biochemistry
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

Mitochondrial Neuropathy

Rotenone is a chemical agent that inhibits mitochondrial electron transport leading to production of reactive oxygen species.  Intravitreal injection of rotenone causes a rapid onset of retinal degeneration. This animal model can be used to test therapeutic intervention on meaningful outcomes including:

  • Quantification of retinal ganglion cells in retinal flatmounts
  • Quantification of retinal thickness by OCT
  • Assessment of retinal function with pattern ERG and full-field ERG
  • Assessment of visual acuity with Optokinetic tracking

In addition to general mitochondrial stress, this is a utilized model for Leber’s hereditary optic neuropathy (LHON) which is an inherited retinal degenerative disorder that causes a progressive loss in visual acuity, and eventual complete loss of vision.  LHON is caused by mitochondrial DNA mutations which lead to retinal cell dysfunction.

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