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EyeCRO Logo

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • Rotenone-induced Optic Neuropathy
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
    • Biochemistry
    • Bioanalytical Detection
    • GLP Toxicology and PK Studies
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

Rotenone-induced Optic Neuropathy

Leber’s hereditary optic neuropathy (LHON) is an inherited retinal degenerative disorder that causes a progressive loss in visual acuity, and eventual complete loss of vision.  LHON is caused by mitochondrial DNA mutations which lead to retinal cell dysfunction.   There are currently no available treatments for LHON, but patients often supplement with antioxidants in an attempt to manage disease onset.

Rotenone is a chemical agent that inhibits mitochondrial electron transport.  Intravitreal injection of rotenone causes a rapid onset of localized ocular defects that recapitulate LHON disease in humans.  This animal model can be used to test therapeutic intervention on clinical outcomes.  Following induction of the disease, visual acuity is monitored by means of optokinetic tracking (OKT), and retinal cell function is monitored by electroretinography (ERG).   Both measures are compared to baseline readings.  Terminal histology measures retinal degeneration. 

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