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  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • Rotenone-induced Optic Neuropathy
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
    • Zucker-fatty Diabetic Retinopathy
  • InVitro Capabilities
    • Bioanalytical Detection
    • Biochemistry
    • GLP Toxicology and PK Studies
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

EyeCRO specializes in preclinical ophthalmic studies to examine the efficacy of novel test agents and therapeutic modalities.  Our models are well established and optimized to facilitate generation of reproducible datasets with meaningful endpoints.
With over two decades of experience in vision research, our expert scientists can help you select the right model and experimental design to achieve your research and development goals.  We also offer Toxicology/PK studies, and eyedrop formulations in MiDROPS™.

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The Global Leader in Preclinical Ophthalmic Research

Microemulsion Drug Ocular Penetration System MiDROPS™

MiDROPS™ was developed to allow for eyedrop formulation of small molecules that are lipophilic.  This technology represents a fundamentally new approach for ophthalmic drug delivery using microemulsions which are thermodynamically stable.  These self-assembling vehicles can formulate high concentrations of drugs and deliver them in abundant quantities to both the anterior segment and posterior segment.  Our broad patents are issued in the US and Worldwide and protect millions of different formulations covered in our library.

midrops vials

Click here to learn more about this innovative platform technology

Models

Allergic Conjunctivitis

Corneal Sensitivity

Corneal Wound Healing

Diabetic Keratopathy

Dry Eye Disease

Endotoxin induced Uveitis

Experimental Autoimmune Uveitis

Geographic Atrophy

Inherited Retinal Degenerations

Ischemia Reperfusion Injury

Laser-induced Choroidal Neovascularization

Light Damaged

Optic Nerve Crush

Oxygen Induced Retinopathy

Retinal Detachment

Retinal Vein Occlusion

Rotenone-induced Optic Neuropathy

STZ-induced Diabetic Retinopathy

VEGF-induced permeability

Zucker-fatty Diabetic Retinopathy

Capabilities

Bioanalytical Detection

Biochemistry

GLP Toxicology and PK Studies

Histology

Ophthalmic Imaging and Physiology

News & Events

Is Treat-and-Extend Truly Effective for Diabetic Macular Edema?

“Anti-vascular endothelial growth factor (anti-VEGF) medications have a proven track record in treating diabetic macular edema (DME). However, researchers continue to investigate whether these medications can be made more efficient and cost-effective.” “Both the RETAIN[1] and REACT[2] studies showed that…

Is Treat-and-Extend Truly Effective for Diabetic Macular Edema?Read More

New Age-Related Macular Degeneration Common in Untreated Fellow Eyes

“NEW YORK (Reuters Health) – New age-related macular degeneration (AMD) develops in about a quarter of fellow eyes to those treated for neovascular AMD with intravitreal anti-VEGF agents, according to a post hoc analysis of the…

New Age-Related Macular Degeneration Common in Untreated Fellow EyesRead More

Double-Barreled Biologic for Diabetic Retinopathy Emerging

CHICAGO — Investigators searching for new ways to manage diabetic macular edema are targeting pathways beyond vascular endothelial growth factor (VEGF). Phase 2 results from the BOULEVARD trial (NCT02699450), which is comparing faricimab, the first biologic to target both…

Double-Barreled Biologic for Diabetic Retinopathy EmergingRead More

FLUID Study Rethinks Treat-and-Extend Protocols in Neovascular AMD

“For patients with neovascular age-related macular degeneration (nAMD), a major cause of visual impairment worldwide,[1] the advent of anti–vascular endothelial growth factor (VEGF) intravitreal injections has been an undeniable breakthrough.  Anti-VEGF therapy allows for greater control of…

FLUID Study Rethinks Treat-and-Extend Protocols in Neovascular AMDRead More

Brolucizumab as Good as Aflibercept for Neovascular AMD

Brolucizumab is noninferior to aflibercept and requires less-frequent injections for patients with neovascular age-related macular degeneration (nAMD), according to results from two phase-3 trials. Earlier this month, Novartis announced that the U.S. Food and Drug Administration…

Brolucizumab as Good as Aflibercept for Neovascular AMDRead More

Drusen Characteristics Linked With AMD Risk in Fellow Eyes

“NEW YORK (Reuters Health) – In patients with unilateral neovascular age-related macular degeneration (AMD), certain drusen features are associated with conversion to neovascular AMD in the fellow eye, according to a secondary analysis of data from…

Drusen Characteristics Linked With AMD Risk in Fellow EyesRead More

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ARVOiovsIOVS Journal@ARVOiovs·
December 7, 2019

New to read: #Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration." Read for free here: https://tinyurl.com/uyhgwly #AMD

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EyeCROEyeCRO@EyeCRO·
December 7, 2019

Functional diversity of human intrinsically photosensitive retinal ganglion cells https://science.sciencemag.org/content/366/6470/1251

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Retweet on TwitterEyeCRO Retweeted
aao_ophthAAO@aao_ophth·
December 3, 2019

Dr. Sunir Garg discusses a smartphone-based AI for diabetic retinopathy screening. http://ow.ly/F1Dk50xqNfJ

Reply on Twitter 1201969462888538113Retweet on Twitter 12019694628885381139Like on Twitter 120196946288853811331Twitter 1201969462888538113
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EyeCRO – Ann Arbor

173 Parkland Plaza, Suite C
Ann Arbor, MI 48103
(734) 997-5455

info@eyecro.com

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