Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models

Experimental and clinical data suggest that pro-angiogenic, pro-inflammatory and mitogenic cytokine leptin can be implicated in ocular neovascularization and the other eye pathologies.  At least in part, leptin action appears to be mediated through functional interplay with vascular endothelial growth factor (VEGF).  The effects of VEGF on leptin expression were assessed in ocular endothelial cell models RF/6A and BCE.  As leptin can in turn activate VEGF, the increased abundance of both cytokines could amplify pro-angiogenic and pro-inflammatory environment in the eye. Thus, combined therapies targeting ObR and VEGF should be considered in the treatment of ocular diseases.

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