Vascular endothelial growth factor A (VEGF-A) is looking like more of an optical troublemaker than ever before – as well as its link with wet age-related macular degeneration (AMD), it also might be causing dry AMD and even age-related cataracts. Therefore, Massachusetts General Hospital researcher and paper author, Dr Alexander Marneros, is looking at what processes create VEGF-A in the eye, to see if tinkering with these could treat this trio of conditions without the unwanted side effects. He has found one – a protein complex known as the NLRP3 inflammasome that, when inactivated, dampens the formation of VEGF.
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