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  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • Rotenone-induced Optic Neuropathy
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
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Preclinical Ophthalmic Contract Research

Preserving photoreceptor cells following retinal injury: Inhibition of alternate complement pathway revealed

July 30, 2015 //  by stanselb

Retinal detachment can occur as a result of either blunt trauma or as a side effect of a variety of ophthalmic diseases, including diabetic retinopathy, ocular tumors, and age-related macular degeneration.  There is a significant increase in the immune system’s ‘alternative complement pathway’ following retinal detachment, researchers report, adding that this pathway facilitated early photoreceptor cell death after injury. Additionally, by blocking the alternative complement pathway, through both genetic and pharmacologic means, photoreceptors were protected from cell death.

Read the entire article here.

Category: NewsTag: Age-related macular degeneration, Diabetic retinopathy, eye diseases, Ophthalmology, photoreceptor cells, Retinal detachment

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