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  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
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    • Experimental Autoimmune Uveitis
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    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Mitochondrial Neuropathy
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    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
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Preclinical Ophthalmic Contract Research

retina

Surgeons perform world’s first operation inside the eye using a robot

September 20, 2016 //  by stanselb

Robert MacLaren, Professor of Ophthalmology. assisted by Dr Thomas Edwards, Nuffield Medical Fellow, used the remotely controlled robot to lift a membrane 100th of a millimetre thick from the retina at the back of the right eye of the Revd Dr William Beaver, 70, an Associate Priest at St Mary the Virgin, Iffley, Oxford. He is the first patient ever to undergo this experimental procedure. Read the …

Category: NewsTag: ophthalmic developement, Ophthalmology, retina

Interim results from clinical trial demonstrate safety of cell-based therapy for retinitis pigmentosa

August 4, 2016 //  by stanselb

Regenerative medicine company jCyte and the Sue & Bill Gross Stem Cell Research Center at the University of California, Irvine report that their investigational therapy for retinitis pigmentosa (RP) has demonstrated a favorable safety and tolerability profile in an ongoing Phase I/II clinical trial.  The cell-based approach taken is intended to rescue sick and dying retinal photoreceptor cells …

Category: NewsTag: ophthalmic disease, rescue retinal photoreceptors, retina, retinitis pigmentosa, RP

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.

June 15, 2016 //  by stanselb

Retinal degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment are being sought actively. Here we explored the activation of a unique protein, sigma 1 receptor (Sig1R), in the treatment of PRC loss because of its multifaceted role in cellular survival.  We used Pde6βrd10 (rd10) mice, which harbor a mutation in the rod-specific phosphodiesterase gene …

Category: NewsTag: blindness, electroretinogram, OCT, ophthalmology research, optical coherence tomography, retina, retinal degeneration

Intraocular therapy prevents or reverses diabetic retinopathy in mice

June 2, 2016 //  by stanselb

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin …

Category: NewsTag: blindness, diabetes, Diabetic retinopathy, ophthalmic research, Ophthalmology, retina, vision loss

Retinal Remodeling And Metabolic Alterations in Human AMD

May 24, 2016 //  by stanselb

Age-related macular degeneration (AMD) is a progressive retinal degeneration resulting in central visual field loss, ultimately causing debilitating blindness.  While many genetic and environmental risk factors are known for AMD, we currently know less about the mechanisms mediating disease progression.  The goal of this article is to illustrate cell types impacted in AMD and demonstrate the …

Category: NewsTag: Age-related macular degeneration, AMD, blindness, ophthalmic research, Ophthalmology, retina, retinal pigment epithelium, retinal remodeling, retinitis pigmentosa, RP, RPE, vision loss

Nerve Injury Appears to be Root of Diabetes-related Vision Loss

April 18, 2016 //  by stanselb

Diabetes-related vision loss most often is blamed on blood vessel damage in and around the retina, but new research indicates that much of that vision loss may result from nerve cell injury that occurs long before any blood vessels are damaged.  After three months on a high-fat diet, the animals had developed obesity-related glucose intolerance, and by six months, they had nerve problems in the …

Category: NewsTag: blindness, blood vessel damage, diabetes-related vision loss, retina, vision loss

Solving Three Major Age-related Eye Conditions in One Go

April 18, 2016 //  by stanselb

Vascular endothelial growth factor A (VEGF-A) is looking like more of an optical troublemaker than ever before – as well as its link with wet age-related macular degeneration (AMD), it also might be causing dry AMD and even age-related cataracts.  Therefore, Massachusetts General Hospital researcher and paper author, Dr Alexander Marneros, is looking at what processes create VEGF-A in the eye, to …

Category: NewsTag: Age-related macular degeneration, AMD, cataracts, CNV lesions, retina, vision

Macular Degeneration Association Issues Urgent Supplement Warning for Patients

March 7, 2016 //  by stanselb

The Macular Degeneration Association, a nonprofit dedicated to preventing blindness, today issued an urgent warning to patients suffering from a form of the disease known as “intermediate dry age-related macular degeneration.”  MDA leaders and ophthalmologists are advising patients to talk with their doctors about a proven and commonly prescribed vitamin supplement containing zinc, an ingredient …

Category: NewsTag: AMD, blindness, cataracts, Diabetic Macular Edema, dry amd, glaucoma, macular degeneration, ophthalmologist, Ophthalmology, retina

First Human Test of Optogenetics Could Restore Sight to the Blind

February 22, 2016 //  by stanselb

Before our brains build a visual image of our world, a chain of cells in our eyes must convert light into electrical signals that are processed in the brain. Photoreceptor cells in the retina represent the first link in this chain, and they are reactive to photons, or the fundamental particle of visible light. Retinitis pigmentosa causes these cells to degenerate, and patients with this …

Category: NewsTag: blind, degenerate, optogenetics, photoreceptor cells, restore sight, retina, retinal degeneration, retinitis pigmentosa, visible light

Scientists Successfully Apply Gene Therapy against Retinitis Pigmentosa

November 3, 2015 //  by stanselb

A collaboration between scientists in the UK and the USA has shown that gene therapy can give life-long protection to the light-sensitive photoreceptor cells responsible for colour vision in a mouse model of the most common inherited eye disorder.

  These findings are significant because they open up a new line of research to prevent nerve cell death in retinitis pigmentosa and age-related …

Category: NewsTag: Age-related macular degeneration, eye disorder, mouse model, Ophthalmology, photoreceptor cells, research, retina, retinitis pigmentosa, rhodopsin

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