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  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
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    • Dry Eye Disease
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    • Experimental Autoimmune Uveitis
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    • Laser-induced Choroidal Neovascularization
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    • Mitochondrial Neuropathy
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Preclinical Ophthalmic Contract Research

Age-related macular degeneration

Retinal Remodeling And Metabolic Alterations in Human AMD

May 24, 2016 //  by stanselb

Age-related macular degeneration (AMD) is a progressive retinal degeneration resulting in central visual field loss, ultimately causing debilitating blindness.  While many genetic and environmental risk factors are known for AMD, we currently know less about the mechanisms mediating disease progression.  The goal of this article is to illustrate cell types impacted in AMD and demonstrate the …

Category: NewsTag: Age-related macular degeneration, AMD, blindness, ophthalmic research, Ophthalmology, retina, retinal pigment epithelium, retinal remodeling, retinitis pigmentosa, RP, RPE, vision loss

Avalanche Biotechnologies Closes Transaction With Annapurna Therapeutics

May 12, 2016 //  by stanselb

Avalanche Biotechnologies, Inc. (AAVL) today announced the closing of the previously announced transaction with Annapurna Therapeutics.  “The new management team is focused on applying our extensive clinical development expertise to advance the company’s gene therapy programs into the clinic.  We intend on dosing our first patients for A1AT deficiency by the end of this year and for HAE in 2017 …

Category: NewsTag: Age-related macular degeneration, Avalanche Biotechnologies, clinical development, eye disease, gene therapy, wet amd

Solving Three Major Age-related Eye Conditions in One Go

April 18, 2016 //  by stanselb

Vascular endothelial growth factor A (VEGF-A) is looking like more of an optical troublemaker than ever before – as well as its link with wet age-related macular degeneration (AMD), it also might be causing dry AMD and even age-related cataracts.  Therefore, Massachusetts General Hospital researcher and paper author, Dr Alexander Marneros, is looking at what processes create VEGF-A in the eye, to …

Category: NewsTag: Age-related macular degeneration, AMD, cataracts, CNV lesions, retina, vision

RetroSense Therapeutics to Present at the 8th Ocular Diseases Drug Discovery Conference

March 14, 2016 //  by stanselb

RetroSense Therapeutics is a privately-held biotechnology company developing life-enhancing gene therapies designed to restore vision in patients suffering from blindness due to retinitis pigmentosa (RP) and advanced dry age-related macular degeneration (advanced dry-AMD).  RetroSense is developing optogenetic approaches to partial vision restoration in retinitis pigmentosa and potentially dry …

Category: NewsTag: Age-related macular degeneration, biotechnology, blindness, dry amd, gene therapies, retinitis pigmentosa, RP, vision

SBIR-STTR Success: Charlesson LLC/EYECRO

November 17, 2015 //  by stanselb

Macular Degeneration is the leading cause of blindness and vision loss in people over 50 –and with life expectancies well into the 80s, it is estimated that 1 and 3 elderly individuals will have to deal with this degenerative disease. The remedy? Monthly injections (via needle) into the back of the eye, where the disease lives. Not only does this method come with the possibility of an infection, …

Category: NewsTag: Age-related macular degeneration, Diabetic retinopathy, MiDROPS, Ophthalmology, ophthalmology research, retinal diseases, vision

Scientists Successfully Apply Gene Therapy against Retinitis Pigmentosa

November 3, 2015 //  by stanselb

A collaboration between scientists in the UK and the USA has shown that gene therapy can give life-long protection to the light-sensitive photoreceptor cells responsible for colour vision in a mouse model of the most common inherited eye disorder.

  These findings are significant because they open up a new line of research to prevent nerve cell death in retinitis pigmentosa and age-related …

Category: NewsTag: Age-related macular degeneration, eye disorder, mouse model, Ophthalmology, photoreceptor cells, research, retina, retinitis pigmentosa, rhodopsin

Scientists find a way to ‘shrink’ blind spot in human eye

September 14, 2015 //  by stanselb

The optic nerve that sends visual signals to the brain must pass through the retina which creates a hole in that light-sensitive layer of tissue. When images project to that precise location, we miss them. This blind spot can be ‘shrunk’ despite the fact that the hole in our visual field cannot be. The findings raise the possibility that similar methods might improve vision in people with …

Category: NewsTag: Age-related macular degeneration, AMD, blindness, ophthalmic, Ophthalmology, optic nerve, retina

Proteomic Studies of Age-Related Ocular Diseases

August 19, 2015 //  by stanselb

A Cleveland Clinic lab has found evidence to support the theory that age-related macular degeneration (AMD) is an inflammatory disease with varying ways to progress to advanced dry and wet AMD.  Focusing on proteomic studies to discover biomarkers and molecular mechanisms of AMD and glaucoma, John W. Crabb, PhD, and his colleagues found many proteins associated with the immune response and …

Category: NewsTag: Age-related macular degeneration, AMD, glaucoma, intraocular pressure, laser-induced, ocular disease, retina, wet amd

Protecting Your Eyes From Macular Degeneration

August 5, 2015 //  by stanselb

Macular degeneration, also known as age-related macular degeneration (or AMD) is the most common cause of vision loss in people over age 50, affecting about 10 million Americans.  While there's currently no cure for AMD there are some things you can do if you're high risk. One option is to talk to your doctor about taking a daily dose of antioxidant vitamins and minerals known as AREDS.  Most drug …

Category: NewsTag: Age-related macular degeneration, dry amd, vision loss, wet amd

Preserving photoreceptor cells following retinal injury: Inhibition of alternate complement pathway revealed

July 30, 2015 //  by stanselb

Retinal detachment can occur as a result of either blunt trauma or as a side effect of a variety of ophthalmic diseases, including diabetic retinopathy, ocular tumors, and age-related macular degeneration.  There is a significant increase in the immune system's 'alternative complement pathway' following retinal detachment, researchers report, adding that this pathway facilitated early …

Category: NewsTag: Age-related macular degeneration, Diabetic retinopathy, eye diseases, Ophthalmology, photoreceptor cells, Retinal detachment

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