Amarantus BioScience Holdings, Inc. announced the presentation of positive preclinical data for MANF (mesencephalic-astrocyte-derived neurotrophic factor) in retinitis pigmentosa (RP) at the Association for Research in Vision and Ophthalmology Annual Meeting, being held in Denver, CO. The results from preclinical studies demonstrate that MANF preserves the light-sensing function of photoreceptor cells in a genetic model of RP.
Rong Wen, M.D., Ph.D., Professor of Ophthalmology, at the Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine, poster on MANF entitled,”ERG preservation by intravitreal injected recombinant mesencephalic astrocyte-derived neurotrophic factor (MANF) in rd10 mice,” disclosed the results of the effect of MANF on the electrophysiological activities of retinal cells in the rd10 mice, a retinal degeneration model of RP carrying the Pde6brd10 mutation. The data demonstrated that intravitreal injection of recombinant human MANF preserves the light-sensing function of photoreceptor cells, as measured by the b-wave amplitude using electroretinography.
Read the entire article here.