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https://eyecro.com

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Mitochondrial Neuropathy
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
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Preclinical Ophthalmic Contract Research

vision loss

Research points towards new blindness prevention methods in diabetic eye disease

December 7, 2016 //  by stanselb

By combining data on optometry patient's eyes with advanced computational methods, Indiana University researchers have created a virtual tissue model of diabetes in the eye. The results, reported in the journal PLOS Computational Biology, show precisely how a small protein that can both damage or grow blood vessels in the eye causes vision loss and blindness in people with diabetes. The study …

Category: News, Top NewsTag: Diabetic retinopathy, ophthalmic research, Ophthalmology, vision loss

Intraocular therapy prevents or reverses diabetic retinopathy in mice

June 2, 2016 //  by stanselb

Pathologic changes of the retina caused by diabetes is the leading cause of blindness in working adults. Diabetic retinopathy has no known cure, treatment options are inadequate, and prevention strategies offer limited protection. In the first of its kind, a report in The American Journal of Pathology describes a potential new intraocular treatment based on manipulating the renin angiotensin …

Category: NewsTag: blindness, diabetes, Diabetic retinopathy, ophthalmic research, Ophthalmology, retina, vision loss

Retinal Remodeling And Metabolic Alterations in Human AMD

May 24, 2016 //  by stanselb

Age-related macular degeneration (AMD) is a progressive retinal degeneration resulting in central visual field loss, ultimately causing debilitating blindness.  While many genetic and environmental risk factors are known for AMD, we currently know less about the mechanisms mediating disease progression.  The goal of this article is to illustrate cell types impacted in AMD and demonstrate the …

Category: NewsTag: Age-related macular degeneration, AMD, blindness, ophthalmic research, Ophthalmology, retina, retinal pigment epithelium, retinal remodeling, retinitis pigmentosa, RP, RPE, vision loss

Nerve Injury Appears to be Root of Diabetes-related Vision Loss

April 18, 2016 //  by stanselb

Diabetes-related vision loss most often is blamed on blood vessel damage in and around the retina, but new research indicates that much of that vision loss may result from nerve cell injury that occurs long before any blood vessels are damaged.  After three months on a high-fat diet, the animals had developed obesity-related glucose intolerance, and by six months, they had nerve problems in the …

Category: NewsTag: blindness, blood vessel damage, diabetes-related vision loss, retina, vision loss

Avalanche Biotechnologies and Annapurna Therapeutics Announce Proposed Merger

November 18, 2015 //  by stanselb

Avalanche Biotechnologies, Inc. (“Avalanche”) (AAVL) and Annapurna Therapeutics SAS (“Annapurna”), a privately held biopharmaceutical company, today announced that they have entered into a definitive agreement providing for the acquisition of all outstanding shares of Annapurna by Avalanche in exchange for approximately 17.6 million newly issued shares of Avalanche common stock.  Upon completion …

Category: NewsTag: biopharmaceutical, ophthalmic, ophthalmic programs, preclinical studies, vision loss

Protecting Your Eyes From Macular Degeneration

August 5, 2015 //  by stanselb

Macular degeneration, also known as age-related macular degeneration (or AMD) is the most common cause of vision loss in people over age 50, affecting about 10 million Americans.  While there's currently no cure for AMD there are some things you can do if you're high risk. One option is to talk to your doctor about taking a daily dose of antioxidant vitamins and minerals known as AREDS.  Most drug …

Category: NewsTag: Age-related macular degeneration, dry amd, vision loss, wet amd

eyecro co-authors paper in Molecular and Cellular Biology studying mechanisms leading to Diabetic Retinopathy

June 12, 2015 //  by stanselb

Serum retinol-binding protein (RBP4) is the sole specific transport protein for retinol in the blood, but it is also an adipokine with retinol-independent, pro-inflammatory activity associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease.  Here we show that RBP4-Tg mice develop progressive retinal degeneration, characterized by photoreceptor ribbon synapse …

Category: NewsTag: diabetic, Ophthalmology, RBP4, retinal degeneration, retinal vascular pathology, serum retinol-binding protein, vision loss

RetroSense Granted Orphan Drug Designation for Retinitis Pigmentosa

November 12, 2014 //  by stanselb

RetroSense Therapeutics, LLC, a privately-held biopharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug designation for the Company’s lead product RST-001 for the treatment of retinitis pigmentosa (RP). Retinitis pigmentosa is a genetic condition which leads to the progressive degeneration of rod and cone photoreceptors (cells found in the …

Category: NewsTag: degeneration, optogenetics, photoreceptors, retina, retinitis pigmentosa, vision loss

Scientists Develop Animal Model for TB-Related Blindness

December 23, 2011 //  by stanselb

Tuberculosis experts at Johns Hopkins and elsewhere have closely mimicked how active but untreated cases of the underlying lung infection lead to permanent eye damage and blindness in people.Lead study investigator and Johns Hopkins infectious disease specialist Petros Karakousis, M.D., says the new animal model should hasten development of a badly needed, early diagnostic test for the …

Category: NewsTag: animal model, inflammation, ocular, tuberculosis, VEGF, vision loss

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