Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy

ByConnor Hodde

“Diabetic retinopathy is a leading cause of vision loss. Previous studies have shown signaling pathways mediated by Stat3 (signal transducer and activator of transcription 3) play a primary role in diabetic retinopathy progression. This study tested CLT-005, a small molecule inhibitor of Stat3, for its dose-dependent therapeutic effects on vision loss in a rat model of diabetic retinopathy.”

Read the entire study here.

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Data Monitoring Committee Recommends Continuation of APOLLO Phase 3 Clinical Trial of Patisiran for Hereditary ATTR Amyloidosis with Polyneuropathy (hATTR-PN)

ByConnor Hodde

CAMBRIDGE, Mass.–(BUSINESS WIRE)– Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY), the leading RNAi therapeutics company, announced today that the Data Monitoring Committee (DMC) for the Phase 3 APOLLO study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN) met on October 7, 2016 and recommended continuation of the trial without modification. Read the entire article here.

Drusen Characteristics Linked With AMD Risk in Fellow Eyes

ByConnor Hodde

“NEW YORK (Reuters Health) – In patients with unilateral neovascular age-related macular degeneration (AMD), certain drusen features are associated with conversion to neovascular AMD in the fellow eye, according to a secondary analysis of data from a clinical trial. Dr. Joelle A. Hallak of the University of Illinois at Chicago and colleagues used machine learning…

Telemedicine Doubles Screening Rates for Retinopathy

ByConnor Hodde

  The use of telemedicine helped a primary care clinic more than double the percentage of diabetic patients undergoing screening for retinopathy over the course of a year, according to a research letter published this month in the Archives of Internal Medicine. The researchers, based out of the University of North Carolina at Chapel Hill,…

Preparation of anti-tumor nanoparticles using tiger milk mushroom

ByConnor Hodde

A recent breakthrough from Hong Kong Polytechnic University uses tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer. A natural compound found in mushrooms may hold the key to a new class of cancer drugs. In Tiger Milk mushrooms from Africa, Dr Wong Ka-hing, Associate Director of the Food Safety and…

Retinitis Pigmentosa: FDA approves first retinal implant for advanced adult RP

ByConnor Hodde

Retinitis pigmentosa (RP) is a group of inherited disorders characterized by progressive peripheral vision loss and night vision difficulties (nyctalopia) that can lead to central vision loss. The US Food and Drug Administration (FDA) has approved the first retinal implant, the Argus II Retinal Prosthesis System, for adults aged 25 years or older with advanced RP. The…