Retinal Detachment

Retinal detachment occurs when the neurosensory retina separates from the underlying retinal pigment epithelium, disrupting nutrient supply and leading to photoreceptor cell death and permanent vision loss if left untreated. Retinal detachment can result from blunt trauma or as a complication of diseases such as diabetic retinopathy, ocular tumors, and age-related macular degeneration.

Model Overview

EyeCRO provides models of transient or sustained retinal detachment to examine the effects of test agents on promoting reattachment and preventing cell death.

Typical Endpoints

  • Optokinetic tracking (visual acuity and contrast sensitivity)
  • Scotopic and photopic ERG
  • OCT analysis of retinal thickness
  • H&E histology (retinal thickness quantification)
  • TUNEL staining (apoptosis quantification)

Representative Data

retinal detachment data

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