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https://eyecro.com

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Mitochondrial Neuropathy
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
    • A2E Quantification
    • Bioanalytical Detection
    • Biochemistry
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

Quantification of A2E Degradation

The deposition of A2E in the retinal pigment epithelium is postulated to contribute to pathology and vision loss observed in Age-Related Macular Degeneration as it is toxic and can induce major inflammatory responses within the eye (See http://www.fasebj.org/content/early/2004/03/05/fj.03-0289fje.long and http://www.pnas.org/cgi/pmidlookup?view=long&pmid=24706818)

The production of A2E is a byproduct of the visual cycle and can be induced through genetically disrupting the function of the ABCA4 gene.  This induces substantial levels of A2E in eyecups by 3-6 months of life.  Utilizing this model, eyecro can deliver test agents through any route of administration (topical, intravitreal, subconjunctival, subretinal, retrobulbar, oral, intravenous, subcutaneous, intraperitoneal) and evaluate the therapeutic effect to reduce A2E formation as measured with specialized HPLC assays performed on eyecups.

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