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https://eyecro.com

  • AboutUs_Normal-24 The EyeCRO Approach
    • About Us
    • Careers
    • Location
    • Partners
  • MiDrops MiDROPS™
  • InVivo Models
    • Allergic Conjunctivitis
    • Corneal Sensitivity
    • Corneal Wound Healing
    • Diabetic Keratopathy
    • DL-AAA Retinal Leakage
    • Dry Eye Disease
    • Endotoxin induced Uveitis
    • Experimental Autoimmune Uveitis
    • Geographic Atrophy
    • Inherited Retinal Degenerations
    • Ischemia Reperfusion Injury
    • Laser-induced Choroidal Neovascularization
    • Light Damaged
    • Mitochondrial Neuropathy
    • Optic Nerve Crush
    • Oxygen Induced Retinopathy
    • Retinal Detachment
    • Retinal Vein Occlusion
    • STZ-induced Diabetic Retinopathy
    • VEGF-induced permeability
  • InVitro Capabilities
    • A2E Quantification
    • Bioanalytical Detection
    • Biochemistry
    • Histology
    • Ophthalmic Imaging and Physiology
  • News News
  • ContactUs Contact Us

Preclinical Ophthalmic Contract Research

Ocular PK and Bioanalytical Services

Pharmacokinetic Services

Understanding the pharmacokinetics of a test article in species typically used in preclinical testing is a necessary component of drug discovery and development. At eyecro, we provide a full pharmacokinetic evaluation service using a wide variety of dose regimens and administration in both rodent and nonrodent species.

Our study directors have access to established colonies of animals ready for immediate use. Also, we have excellent surgical capabilities enabling us to offer multiple routes for sample collection.

Our experienced team of scientists design and conduct pharmacokinetic studies to examine many parameters including: dose proportionality, bioavailability, and food effects. Steady state, continuous infusion, and multiple dose test article administration can be calculated and verified in-vivo.

Study Types

Pharmacokinetics / toxicokinetics

  • Compartmental
  • Non-compartmental
 Ocular Tissue Distribution
  • Animals: Mouse, Rat, Rabbit
  • Evaluation:
    • Ocular tissue dissection (retina, vitreous, lens, cornea, sclera)
    • Quantification of therapeutic by LC-MS/MS
 Quantification in Plasma
  • Animals: Rat, Rabbit
  • Evaluation: Quantification of therapeutic by LC-MS/M

The team at eyecro is also skilled at performing ophthalmic pharmacokinetic and tissue distribution studies in both rodents and rabbits with the ability to perform LC-MS/MS quantification of test agents in various tissues of the eye and plasma.

 

AH PK

Bioanalytical Studies

bioanalytical studies

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