Ocular Angiogenesis Models

Laser-Induced Choroidal Neovascularization

The laser-induced choroidal neovascularization (CNV) model is a classic animal model used to examine the efficacy of compounds in the prevention of neovascularization.

Animals:

Rat

 

End Points:

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  • Neovessel area on choroidal flat mounts
  • fluorescein angiography
  • H&E histology
  • Immunohistochemistry for inflammatory markers
Preclinical Ophthalmic Contract Research