Inherited Retinal Degeneration Models

Mouse Model Of Retinitis Pigmentosa

End Points:

  • ERG
  • Quantitative H&E histology
  • Immunohistochemistry
  • Retinoid profiling
  • Quantification of phototransduction genes/protein expression by qRT-PCR/Immunoblot

 

Mouse Model of Rpe65 Deficiency

 

End Points:

  • ERG
  • Quantitative H&E histology
  • Immunohistochemistry
  • Retinoid profiling
  • Quantification of phototransduction genes/protein expression by qRT-PCR/Immunoblot
  • Quantification of RPE65 isomerase activity

 

Rat Model of Retinitis Pigmentosa P23H – Line one from Dr. Matt LaVail

 

End Points:

  • ERG
  • Quantitative H&E histology
  • Immunohistochemistry
  • Retinoid profiling
  • Quantification of phototransduction genes/protein expression by qRT-PCR/Immunoblot

 

Mouse Model Stargardt’s Macular Degeneration Disease

 

End Points:

  • ERG
  • Quantitative H&E histology
  • Immunohistochemistry
  • Retinoid profiling
  • Quantification of phototransduction genes/protein expression by qRT-PCR/Immunoblot
Preclinical Ophthalmic Contract Research