PLGA Nanoparticles

Poly(lactic-co-glycolic acid) is a copolymer which is used in a wide array of FDA approved therapeutic devices. PLGA is a biodegradable, biocompatibility polymer that by hydrolysis of its ester linkages in the presence of water. It has been shown that the time required for degradation of PLGA is related to the monomers’ ratio used in production: the higher the content of glycolide units, the lower the time required for degradation.

We can produce nanoparticles in the range of 100 to 300 nm in size. We have developed proprietary technology to allow us to incorporated hydrophobic drugs with the ability to tailor the drug loading from 10% to 40% w/w. In-vitro release profiles for our hydrophobic drugs shows in-vitro release of the drug for over 6 months.

We have also developed technology to incorporate peptides into the nanoparticles and have shown therapeutic effects in rat models for 4 weeks.

PLGA Nanoparticles
 
PLGA Nano Graph

Preclinical Ophthalmic Contract Research